Fate of 2-deoxy-2-[18F]fluoro-D-glucose in hyperglycemic rats

Sustained hyperglycemia allows the preferential labelling of pancreatic glycogen by D-[U-14C]glucose in control rats, as compared to animals previously injected with streptozotocin (STZ rats). The major aim of the present study was to investigate whether a sizeable difference between control and STZ...

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Bibliographic Details
Published inInternational journal of molecular medicine Vol. 6; no. 5; p. 549
Main Authors Malaisse, W J, Damhaut, P, Ladriere, L, Goldman, S
Format Journal Article
LanguageEnglish
Published Greece 01.11.2000
Subjects
Animals
Diabetes Mellitus, Experimental - metabolism
Female
Fluorine Radioisotopes - pharmacokinetics
Fluorodeoxyglucose F18 - pharmacokinetics
Glycogen - biosynthesis
Hyperglycemia - metabolism
Pancrelipase - metabolism
Rats
Rats, Wistar
Tissue Distribution
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Summary:Sustained hyperglycemia allows the preferential labelling of pancreatic glycogen by D-[U-14C]glucose in control rats, as compared to animals previously injected with streptozotocin (STZ rats). The major aim of the present study was to investigate whether a sizeable difference between control and STZ rats could also be observed in terms of the radioactive content of the pancreatic gland 8 h after the intravenous injection of 2-deoxy-2-[18F]fluoro-D-glucose, both types of animals being examined at the same level of hyperglycemia. Although the radioactive content of muscle, liver and kidney was lower in STZ rats than in control animals, such a difference failed to achieve statistical significance in brain, hypophysis, pancreas and parotid gland. It is proposed, therefore, that 11C-labelled D-glucose, rather than 2-deoxy-2-[18F]fluoro-D-glucose should be used in the perspective of the non-invasive imaging of the endocrine pancreas.
ISSN:1107-3756
DOI:10.3892/ijmm.6.5.549