Diurnal variation of the tear osmolarity in normal subjects measured by a new microchip system

• Published in: European journal of ophthalmology Vol. 22 Suppl 7; p. S1
• Main Authors: Oncel, Banu Açikalin, Pinarci, Eylem, Akova, Yonca A
• Format: Journal Article
• Language: English
• Published: United States 2012
• Subjects: Adolescent; Adult; Circadian Rhythm - physiology; Diagnostic Techniques, Ophthalmological - instrumentation; Humans; Lab-On-A-Chip Devices; Male; Middle Aged; Osmolar Concentration; Reference Values; Tears - chemistry; Young Adult
• DOI: 10.5301/ejo.5000084

To show the diurnal variation of tear osmolarity in normal subjects. Thirty volunteers were recruited. Tear osmolarity was measured with TearLab osmolarity system at 3-hour regular intervals between 8:00 am and 5:00 pm. One-way analysis of variance test was used for statistical analysis. Thirty healthy volunteers (all men) with a mean age of 29.6 ± 4.3 years (range 18-45) were recruited. The difference between measurements at 8:00 am and 11:00 am, 8:00 am and 2:00 pm, 8:00 am and 5:00 pm, 11:00 am and 2:00 pm, 11:00 am and 5:00 pm, and 2:00 pm and 5:00 pm were not statistically significant (one-way analysis of variance test, p>0.05). In normal subjects, tear osmolarity seems to have a stable profile during the daytime.