Distinct dietary risk factors for incident osteoporotic fractures in early and late postmenopausal phase women
Introduction Available evidence on favorable nutritional factors for preventing osteoporosis remains controversial. Considering the recent increases in life expectancy, we investigated the relationship between incident osteoporotic fractures and dietary habits in early and late postmenopausal phase...
Saved in:
Published in | Journal of bone and mineral metabolism Vol. 41; no. 2; pp. 227 - 238 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Singapore
Springer Nature Singapore
01.03.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Introduction
Available evidence on favorable nutritional factors for preventing osteoporosis remains controversial. Considering the recent increases in life expectancy, we investigated the relationship between incident osteoporotic fractures and dietary habits in early and late postmenopausal phase women.
Materials and methods
Subjects were Japanese postmenopausal outpatients recruited at a primary care institution in Nagano Prefecture (Nagano Cohort Study). Patients with critical or acute illness or secondary osteoporosis were not included in this study. In total, 1,071 participants were prospectively followed for a mean of 5.8 years. The cohort was divided into early (≤ 70 years) and late (> 70 years) postmenopausal phases based on median age. Dietary nutrient intake was estimated by the food frequency questionnaire method. According to baseline nutrient intake characteristics, we focused on protein/energy and Ca/NaCl intake ratios, which were also divided by the median values.
Results
Kaplan–Meier plots revealed a significantly higher occurrence of fractures for the high protein/energy intake group in early postmenopausal subjects (
P
= 0.009), whereas the low Ca/NaCl intake group in late postmenopausal subjects exhibited a significantly earlier occurrence of fractures (
P
= 0.002). Multivariate Cox regression uncovered significant independent risks of higher protein/energy (HR 1.35; 95% CI 1.04–1.74) and lower Ca/NaCl (HR 0.79; 95% CI 0.63–0.99) intake ratios for incident osteoporotic fractures in the early and late postmenopausal cohorts, respectively.
Conclusion
Distinct dietary risk factors for osteoporotic fractures were identified in early and late postmenopausal phase women. Appropriate nutritional guidance according to patient age will be important for maintaining bone health and quality of life. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0914-8779 1435-5604 |
DOI: | 10.1007/s00774-023-01400-7 |