Histopathology of the thymus of coho salmon Oncorhynchus kisutch experimentally infected with Renibacterium salmoninarum

We report on the histopathological changes occurring in the thymus of coho salmon Oncorhynchus kisutch experimentally infected with Renibacterium salmoninarum. Coho salmon were intraperitoneally infected, and the thymi were collected weekly from 1 to 7 wk post-infection, and processed for ultrastruc...

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Published inDiseases of aquatic organisms Vol. 26; no. 1; pp. 11 - 18
Main Authors FLANO, E, KAATTARI, S. L, RAZQUIN, B, VILLENA, A. J
Format Journal Article
LanguageEnglish
Published Oldendorf Inter-Research 1996
Subjects
Animal bacterial diseases
Bacterial diseases
Biological and medical sciences
Freshwater
Infectious diseases
Medical sciences
Oncorhynchus kisutch
Renibacterium salmoninarum
Thymus gland
Oncorhynchus kisutch
Renibacterium salmoninarum
Infection
Vertebrata
Experimental disease
Histopathology
Ultrastructure
Pisces
Pathogenic
Infectivity
Bacteriosis
Bacteria
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Summary:We report on the histopathological changes occurring in the thymus of coho salmon Oncorhynchus kisutch experimentally infected with Renibacterium salmoninarum. Coho salmon were intraperitoneally infected, and the thymi were collected weekly from 1 to 7 wk post-infection, and processed for ultrastructural study. The thymus appeared to be infected only in fish collected at 6 and 7 wk post-infection. The first stage of the infection was characterized by the presence of a low number of bacteria scattered in the connective tissue of the capsule. Further progression of the thymic infection was characterized by the rupture of the capsular-thymic barrier, and by the bacterial colonization of the subcapsular and inner zones of the parenchyma, where the bacteria were located mainly in macro-phages, but also apparently in pale reticular-epithelial cells and in thymocytes. Other reticular-epithelial cells, and the vascular trabeculae, remained free of R. salmoninarum during the initial stages of the infection. In severely infected thymi, necrosis of the parenchyma of the subcapsular and inner zones, and bacterial invasion of the trabeculae occurred. The integrity of the pharyngeal epithelium covering the thymus was not affected during the infection.
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ISSN:0177-5103
1616-1580
DOI:10.3354/dao026011