Anti-phospholipase A2 and anti-inflammatory activity of Santolina chamaecyparissus

• Published in: Life sciences (1973) Vol. 66; no. 2; pp. PL35 - PL40
• Main Authors: Sala, A, Recio, M C, Giner, R M, Máñez, S, Ríos, J L
• Format: Journal Article
• Language: English
• Published: Netherlands 2000
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Asteraceae - chemistry; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - isolation & purification; Enzyme Inhibitors - pharmacology; Female; Flavonoids - chemistry; Flavonoids - isolation & purification; Flavonoids - pharmacology; Mice; Phospholipases A - antagonists & inhibitors; Phospholipases A2; Plant Extracts - pharmacology; Plants, Medicinal - chemistry; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology

The activity of the Santolina chamaecyparissus methanol extract was tested against the phospholipase A2 (PLA2)-induced mouse paw edema and in vitro inhibition of PLA2 activity. After fractionation, only the dichloromethane extract was active against the PLA2 in vitro test. In addition, it reduced th...