Fusidic acid in dermatology: an updated review

• Published in: EJD. European journal of dermatology Vol. 20; no. 1; p. 6
• Main Authors: Schöfer, Helmut, Simonsen, Lene
• Format: Journal Article
• Language: English
• Published: France 01.01.2010
• Subjects: Administration, Oral; Administration, Topical; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - therapeutic use; Drug Combinations; Fusidic Acid - administration & dosage; Fusidic Acid - therapeutic use; Glucocorticoids - administration & dosage; Humans; Skin Diseases, Infectious - drug therapy
• ISSN: 1167-1122
• DOI: 10.1684/ejd.2010.0833

Studies on the clinical efficacy of fusidic acid in skin and soft-tissue infections (SSTIs), notably those due to Staphylococcus aureus, are reviewed. Oral fusidic acid (tablets dosed at 250 mg twice daily, or a suspension for paediatric use at 20 mg/kg/day given as two daily doses) has shown good efficacy and tolerability. Similarly, plain fusidic acid cream or ointment used two or three times daily in SSTIs such as impetigo are clinically and bacteriologically effective, with minimal adverse events. Combination formulations of fusidic acid with 1% hydrocortisone or 0.1% betamethasone achieve excellent results in infected eczema by addressing both inflammation and infection. A new lipid-rich combination formulation provides an extra moisturizing effect. Development of resistance to fusidic acid has remained generally low or short-lived and can be minimized by restricting therapy to no more than 14 days at a time.