Structural and functional analysis of a new retrotransposon class in Drosophila species

Several copies of the Penelope transposable element, previously described in Drosophila virilis, have been studied in different D. virilis strains and D. melanogaster strains transformed with P-based constructs bearing a full-size Penelope copy. Most Penelope copies in both species have large termin...

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Published inMolecular biology (New York) Vol. 43; no. 2; pp. 329 - 338
Main Authors Ravin, V. K, Sukchev, M. B, Zelentsova, E. S, Shostak, N. G, Evgen'ev, M. B
Format Journal Article
LanguageEnglish
Published Dordrecht Dordrecht : SP MAIK Nauka/Interperiodica 01.04.2009
SP MAIK Nauka/Interperiodica
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Drosophila virilis
Genes
Genomics
Human Genetics
Insects
Life Sciences
Studies
To the Anniversary of the Institute Of Molecular Biology
transposable elements
retrotransposons
evolution
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Summary:Several copies of the Penelope transposable element, previously described in Drosophila virilis, have been studied in different D. virilis strains and D. melanogaster strains transformed with P-based constructs bearing a full-size Penelope copy. Most Penelope copies in both species have large terminal inverted repeats (TIRs) and deletions of various sizes at the 5' ends of their ORFs. Junctions between TIRs and ORFs usually have microhomologies of various lengths, which allowed a hypothesis explaining the emergence of these complex structures at the molecular level to be put forward. Most Penelope copies have a 34 bp long direct repeat at the ORF ends. Full-size and truncated Penelope copies are usually surrounded by target site duplications of various lengths.
Bibliography:http://dx.doi.org/10.1134/S0026893309020150
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ISSN:0026-8933
1608-3245
DOI:10.1134/S0026893309020150