Variation in Prevalence of Rare Heritable Traits — A Simulation Study — Illustrated by Neurofibromatosis Type 1

The epidemiology of heritable traits whose prevalence is determined by a balance between mutation and selection is often explored through deterministic models. Here, the properties are explored by simulation of a model population followed through a sequence of closely spaced time points. Mutation an...

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Bibliographic Details
Published inTwin research and human genetics Vol. 22; no. 4; pp. 229 - 232
Main Author Stark, Alan E.
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 01.08.2019
Subjects
Female
Finland - epidemiology
Genetics, Population
Humans
Male
Models, Genetic
Mutation - genetics
Neurofibromatosis 1 - epidemiology
Neurofibromatosis 1 - genetics
Prevalence
Finland
autosomal
rare deleterious trait
Prevalence
dominant
neurofibromatosis 1
Finland
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Summary:The epidemiology of heritable traits whose prevalence is determined by a balance between mutation and selection is often explored through deterministic models. Here, the properties are explored by simulation of a model population followed through a sequence of closely spaced time points. Mutation and birth and death occur randomly. The condition neurofibromatosis type 1 (NF1) is used as a point of reference. Critical parameters, such as mutation rates and selection forces, are not known precisely for NF1 so speculative values based on published data from Finland and other studies are proposed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1832-4274
1839-2628
DOI:10.1017/thg.2019.47