Bioactive Natural Products from Endophytic Fungus Aspergillus nidulans Associated with Nyctanthes arbor-tristis Linn

Endophytic fungi are a substantial source of bioactive secondary metabolites. Present studies on Aspergillus nidulans―an endophytic fungus from Nyctanthes arbor-tristis Linn. afforded one new 1, 5-dihydroxy-3-methylxanthone-6-carboxylic acid methyl ester (1) and one known 5, 10-dihydro-phenazine-1-c...

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Published inRecords of natural products Vol. 15; no. 6; pp. 608 - 612
Main Authors Sana, Talea, Siddiqui, Bina, Khan, Majid, Shahzad, Saleem, Sattar, Samia, Begum, Sabira
Format Journal Article
LanguageEnglish
Published Gebze ACG Publications 01.11.2021
Subjects
Biological products
Chemical compounds
Fungi
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Summary:Endophytic fungi are a substantial source of bioactive secondary metabolites. Present studies on Aspergillus nidulans―an endophytic fungus from Nyctanthes arbor-tristis Linn. afforded one new 1, 5-dihydroxy-3-methylxanthone-6-carboxylic acid methyl ester (1) and one known 5, 10-dihydro-phenazine-1-carboxylic acid (2) compound. The structures were elucidated by spectral techniques (Mass, 1D and 2D NMR), and their urease, carbonic anhydrase and prolyl endopeptidase inhibitory activities were evaluated. Compound 1 showed notable prolyl endopeptidase inhibition (IC50 = 3.13 ± 0.09 µM) and compound 2 showed significant carbonic anhydrase (IC50 =14.3 ± 1.05 µM) and urease (IC50 = 24.3 ± 1.15 µM) inhibition.
ISSN:1307-6167
1307-6167
DOI:10.25135/rnp.251.21.02.1986