African Ancestry Is a Predictor Factor to Secondary Progression in Clinical Course of Multiple Sclerosis

Background. Studies on the clinical course of multiple sclerosis have indicated that certain initial clinical factors are predictive of disease progression. Regions with a low prevalence for disease, which have environmental and genetic factors that differ from areas of high prevalence, lack studies...

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Published inISRN neurology Vol. 2012; pp. 410629 - 7
Main Authors Ferreira Vasconcelos, Claudia Cristina, Cruz dos Santos, Gutemberg Augusto, Thuler, Luiz Claudio, Camargo, Solange Maria, Papais Alvarenga, Regina Maria
Format Journal Article
LanguageEnglish
Published Egypt International Scholarly Research Network 2012
Hindawi Limited
Subjects
Age
Clinical Study
Demography
Disease
Evolution
Genealogy
Genetic factors
medical records
Multiple sclerosis
Multivariate analysis
pharmacogenomics
Population
Prognosis
Statistical methods
Studies
Survival
Variables
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Summary:Background. Studies on the clinical course of multiple sclerosis have indicated that certain initial clinical factors are predictive of disease progression. Regions with a low prevalence for disease, which have environmental and genetic factors that differ from areas of high prevalence, lack studies on the progressive course and disabling characteristics of the disease. Objective. To analyse the long-term evolution to the progressive phase of the relapsing-remitting multiple sclerosis and its prognosis factors in mixed population. Methods. We performed a survival study and logistic regression to examine the influence of demographic and initial clinical factors on disease progression. Among 553 relapsing-remitting patients assisted at a Brazilian reference centre for multiple sclerosis, we reviewed the medical records of 150 patients who had a disease for ten or more years. Results. African ancestry was a factor that conferred more risk for secondary progression followed by age at the onset of the disease and the number of relapses in the year after diagnosis. A greater understanding of the influence of ancestry on prognosis serves to stimulate genetics and pharmacogenomics research and may clarify the poorly understood neurodegenerative progression of MS.
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Academic Editors: K. R. Pennypacker and J. E. Riggs
ISSN:2090-5513
2090-5505
2090-5513
DOI:10.5402/2012/410629