Thin-layer chromatographic separation of ferrocene derivatives

• Published in: BUNSEKI KAGAKU Vol. 20; no. 3; pp. 278 - 281
• Main Authors: TANIKAWA, Keiichi, ARAKAWA, Kiichi
• Format: Journal Article
• Language: English; Japanese
• Published: Tokyo The Japan Society for Analytical Chemistry 1971; Japan Science and Technology Agency
• ISSN: 0525-1931
• DOI: 10.2116/bunsekikagaku.20.278

Derivatives of ferrocene were separated by thin-layer chromatography by using Merck TLC plates silica gel F254. The separation of monosubstitutes and disubstitutes were done by the development with petroleum benzine-ethanol (30 : 1), petroleum benzine-methanol (30 : 1) petroleum benzine-acetone (30 : 4) or toluenepetroleum benzine-acetone (30 : 2 : 2), whereby the Rf values of monosubstitutes were generally greater. The raw materials and intermediates in the synthesis of ferrocene derivatives were also separated. Rf values of various compounds obtained during the course of synthesis of 1, 1'-di(α-hydroxymethyl) ferrocene by the development with mixed solvents were in the order : ferrocene>1-methyl-1'-ferrocene carboxylic acid>1, 1'-diacetyl ferrocene >1, 1'-di(a-hydroxy-methyl)ferrocene.