Research note: effect of 2,4-dinitrophenol on growth and body composition of broilers

• Published in: Poultry science Vol. 71; no. 6; pp. 1096 - 1100
• Main Authors: Toyomizu, M, Okamoto, K, Tanaka, M, Ishibashi, T
• Format: Journal Article
• Language: English
• Published: England 01.06.1992
• Subjects: 2,4 dinitrofenol; 2,4 dinitrophenol; adenosindifosfato; adenosine diphosphate; adenosine triphosphate; adenosintrifosfato; Adipose Tissue - drug effects; Adipose Tissue - growth & development; adipose tissues; Animals; Body Composition - drug effects; broiler chickens; carcass composition; Chickens - anatomy & histology; Chickens - growth & development; composicion de la canal; composition de la carcasse; consommation d' oxygene; consumo de oxigeno; Dinitrophenols - pharmacology; dnp; efficacite alimentaire; eficiencia de conversion del pienso; feed conversion efficiency; feed intake; Female; foie; gain de poids; ganancia de peso; higado; ingestion de pienso; liver; Male; mitochondria; Mitochondria, Liver - drug effects; Mitochondria, Liver - metabolism; Mitochondria, Muscle - drug effects; Mitochondria, Muscle - metabolism; mitochondrie; mitocondria; muscle; muscles; musculos; oxygen consumption; Oxygen Consumption - drug effects; pollo de engorde; poulet de chair; prise alimentaire animaux; tejido adiposo; tissu adipeux; Uncoupling Agents - pharmacology; weight gain; Weight Gain - drug effects
• ISSN: 0032-5791; 1525-3171
• DOI: 10.3382/ps.0711096

The effects of 2,4-dinitrophenol (DNP) on growth feed efficiency, fattening, and mitochondrial function of the liver and skeletal muscle were studied in broilers. The DNP was added at levels of 100, 200, and 400 mg/kg of diet. Feed intake was not changed with administration of DNP except at 100 mg/kg of diet. Body weight was significantly decreased by administration of DNP at 400 mg/kg of diet compared with those at 0 and 100 mg/kg of diet Feed efficiency was significantly reduced by administration of DNP at 400 mg/kg of diet. Abdominal fat and carcass fat contents, expressed either as absolute values or relative percentages of body weight, were significantly decreased with increasing dietary DNP concentration above 200 mg/kg of diet. These results showed that administration of DNP reduced body fat, which may be associated with the change m feed efficiency No reduction in adenosine triphosphate:oxygen ratio with increasing DNP concentration was observed in hepatic and skeletal muscle mitochondria isolated from broilers fed experimental diets containing DNP.