Saponin, Polyphenol, Flavonoid content and α-glucosidase Inhibitory Activity, Antioxidant Potential of Launaea sarmentosa Leaves grown in Ben Tre province, Vietnam

Launaea sarmentosa (Willd) Schultz-Bip.ex Kuntze, a creeping herb, belongs to family Asteraceae. It is distributed in sandy coasts of India, Sri Lanka, Malaysia, East Africa and Vietnam. In Vietnamese folk medicine, whole plant possess tonic, soporific, diuretic, laxative properties and the roots ar...

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Published inIOP conference series. Materials Science and Engineering Vol. 542; no. 1; pp. 12036 - 12040
Main Authors Them, Le Thi, Tuong Nguyen Dung, Phu, Thi Nhat Trinh, Pham, Tong Hung, Quach, Tuong Vi, Le Nguyen, Trong Tuan, Nguyen, Duc Lam, Tri, Thuy Nguyen, Van, Dung, Le Tien
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.06.2019
Subjects
Antioxidants
Childbirth & labor
Diuretics
Enzyme activity
Ethanol
Flavonoids
Glucosidase
Phytochemicals
Saponins
Vietnam
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Summary:Launaea sarmentosa (Willd) Schultz-Bip.ex Kuntze, a creeping herb, belongs to family Asteraceae. It is distributed in sandy coasts of India, Sri Lanka, Malaysia, East Africa and Vietnam. In Vietnamese folk medicine, whole plant possess tonic, soporific, diuretic, laxative properties and the roots are used to benefit milk for mothers after childbirth, instead of Lactuca indica. Up to now, the phytochemicals and bioactivities of this plant are not yet been examined. The present study was designed to investigate the saponin, polyphenol and flavonoid contents as well as α-glucosidase inhibitory and antioxidant activities of the leaves of L. sarmentosa. Preliminary phytochemical screening of this plant were found to give positive reactions for flavonoid, saponin, alkaloid, tannin, and steroid compounds. The result of quantitative determination showed that the leaves contains high amount of polyphenol compounds (290.90 mg GAEs/g extract), lower amount of flavonoids (85.47 mg QEs/g extract) and the saponin content was found to be 10.8 % (per dry weight). As expected, the ethanol extract had a antioxidant potential with IC50 value of 24.15 μg/mL in DPPH experiment, compared to that of vitamin C. Meanwhile, the α-glucosidase inhibitory assay showed inhibited enzyme activity with IC50 value of 67.09 μg/ml.
ISSN:1757-8981
1757-899X
DOI:10.1088/1757-899X/542/1/012036