Formation and synthesis of 3'-t-butyltyrosine

During acidolysis by TFA of the t-butyl protecting group from Z-Tyr(But) or from Ser (But) in the presence of tyrosine, C-t-butylation occurred in the aromatic nucleus in Z-Tyr or tyrosine, respectively, to an extent of 0.5-1.0%. CF3COOBut formed during the acidolysis slowly C-t-butylates tyrosine....

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Bibliographic Details
Published inInternational journal of peptide and protein research Vol. 14; no. 4; p. 344
Main Authors Lundt, B F, Johansen, N L, Markussen, J
Format Journal Article
LanguageEnglish
Published Denmark 01.10.1979
Subjects
Chemical Phenomena
Chemistry
Spectrum Analysis
Tyrosine - analogs & derivatives
Tyrosine - chemical synthesis
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Summary:During acidolysis by TFA of the t-butyl protecting group from Z-Tyr(But) or from Ser (But) in the presence of tyrosine, C-t-butylation occurred in the aromatic nucleus in Z-Tyr or tyrosine, respectively, to an extent of 0.5-1.0%. CF3COOBut formed during the acidolysis slowly C-t-butylates tyrosine. Tyr(3'But) is formed. The synthesis of Tyr (3'But) . HCl is described.
ISSN:0367-8377
DOI:10.1111/j.1399-3011.1979.tb01942.x