Hydrogel film of polyethylene oxide-polypropylene glycol diacrylate for wound dressing application

• Published in: IOP conference series. Materials Science and Engineering Vol. 403; no. 1; pp. 12014 - 12018
• Main Authors: Haryanto, Aini, A N
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.09.2018
• Subjects: Biocompatibility; Composition; Electron beams; Electron irradiation; Hydrogels; Polyethylene; Polyethylene oxide; Polypropylene glycol; Swelling ratio; Water vapor; Wound healing
• ISSN: 1757-8981; 1757-899X; 1757-899X
• DOI: 10.1088/1757-899X/403/1/012014

Hydrogel polymer receives more attention in medical and other applications due to its biocompatibility properties and swelling ratio. Hydrogel has an ability to absorb and retain water, a property which is very useful for medical applications. We developed polyethylene oxide (PEO)-polypropylene glycol diacrylate (PPGDA) hydrogel film through electron beam irradiation for wound dressing application. Various compositions of PPGDA/PEO (0%, 5%, 10%, 15% and 20%) were irradiated using electron beam to obtain the optimum composition for a better hydrogel characteristic. The PPGDA content in the hydrogel film influences the level of swelling capacity, gel fraction and mechanical strength. The results show that 20% PPGDA content of hydrogel film has the highest mechanical strength (6,2 N/mm2). The composition of 20% PPGDA hydrogel film also has the highest gel fraction (79%). However, the hydrogel prepared using that composition has the lowest swelling ratio (300%). Based on the results, 20% PPGDA hydrogel film is very potential for wound dressing application with high mechanical strength and ideal water vapor transmission rate.