Antioxidant potency of various mangosteen (Garcinia mangostana,L) pericarp extract fractions on HbA1c and fasting blood glucose level in diabetic mice

This study is purposed to explore the antioxidant potency of various mangosteen (Garcinia mangostana L) pericarp extract fractions on HbA1c and fasting blood glucose level in diabetic mice. Study conducted using 3-4 months old male mice as models. Animal models split into 2 main groups; non-STZ norm...

Full description

Saved in:
Bibliographic Details
Published inIOP conference series. Earth and environmental science Vol. 259; no. 1; pp. 12001 - 12005
Main Authors Husen, S A, Hayaza, S, Susilo, J K, Setyawan, F, Zuraidah, A A, Winarni, D, Darmanto, W
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.05.2019
Subjects
Animal models
Antioxidants
Blood
Blood glucose
Body weight
Diabetes
Diabetes mellitus
Dosage
Fasting
Garcinia mangostana
Glucose
Hemoglobin
Metformin
Pericarp
Physical growth
Rodents
Subgroups
Online AccessGet full text

Cover

More Information
Summary:This study is purposed to explore the antioxidant potency of various mangosteen (Garcinia mangostana L) pericarp extract fractions on HbA1c and fasting blood glucose level in diabetic mice. Study conducted using 3-4 months old male mice as models. Animal models split into 2 main groups; non-STZ normal control group and STZ-treated diabetic mice. STZ induced via multiple low dose method of 30 mg/kg BW administered for 5 days (given daily). Diabetic mice group then divided into 3 subgroups, which were diabetic control group, Metformin-HCl diabetic group, and treatment group given with various mangosteen pericarp extract fractions. Treatment group separated into 3 groups based on various fraction administered; 18 mg/kg BW non-polar (NP) fraction, 80 mg/kg BW semi-polar (SP) fraction, and 50 mg/kg BW polar (P) fraction. All fraction dose equals to 2.5 gram/kg BW of powdered mangosteen pericarp extract dry weight. Control group and various extract fractions treated for 14 days. Body weight, HbA1c, and fasting blood glucose level (after mice fasted for 5-6 hours) measured on 15th day. Result shows significant differences on HbA1c and fasting blood glucose level of treatment group compared to control group, specifically non-polar and polar fraction treatment significantly reduce HbA1c and fasting blood glucose level of diabetic mice.
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/259/1/012001