Melatonin does not affect in vitro secretion of testosterone in white-footed mouse testis

There is evidence that melatonin may exert its antigonadal effect by acting in the gonad to inhibit steroidogenesis. To explore this possibility a hormonally sensitive in vitro system of dispersed Peromyscus leucopus testis was used to assess the effects of melatonin on human chorionic gonadotropin...

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Bibliographic Details
Published inJournal of pineal research Vol. 5; no. 6; p. 521
Main Authors Knotts, L K, Bruot, B C, Glass, J D
Format Journal Article
LanguageEnglish
Published England 01.11.1988
Subjects
Animals
Bucladesine - pharmacology
Chorionic Gonadotropin - pharmacology
In Vitro Techniques
Male
Melatonin - pharmacology
Peromyscus - physiology
Reference Values
Testis - drug effects
Testis - secretion
Testosterone - secretion
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Summary:There is evidence that melatonin may exert its antigonadal effect by acting in the gonad to inhibit steroidogenesis. To explore this possibility a hormonally sensitive in vitro system of dispersed Peromyscus leucopus testis was used to assess the effects of melatonin on human chorionic gonadotropin (hCG)- and dibutyryl-cAMP (dbcAMP)-stimulated secretion of testosterone (T). At near-maximally stimulating doses of hCG and dbcAMP, melatonin in concentrations of 2 x 10(-12) M to 2 x 10(-7) M did not affect the rate of secretion of T in cells from active or regressed testes. These results do not support the idea that melatonin helps to regulate seasonal reproduction by acting in the testes to inhibit steroidogenesis.
ISSN:0742-3098
1600-079X
DOI:10.1111/j.1600-079X.1988.tb00794.x