Chemotactic response of vascular smooth muscle cells to acetoacetylated low-density lipoprotein
We studied the effect of acetoacetylated low-density lipoprotein (LDL), which is recognized by the scavenger receptor, on the migration of fetal bovine aortic smooth muscle cells in culture, using a Neuro Probe 48-well microchemotaxis chamber. Acetoacetylated LDL is chemotactic and chemokinetic for...
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| Published in | Heart and vessels Vol. 4; no. 2; p. 100 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japan
01.06.1988
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| Subjects | |
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| Abstract | We studied the effect of acetoacetylated low-density lipoprotein (LDL), which is recognized by the scavenger receptor, on the migration of fetal bovine aortic smooth muscle cells in culture, using a Neuro Probe 48-well microchemotaxis chamber. Acetoacetylated LDL is chemotactic and chemokinetic for the smooth muscle cells, and the effect is maximal with 50 micrograms/ml of protein, while native LDL has no significant chemotactic activity. These results suggest that denatured LDL might play an important role in the recruitment of smooth muscle cells from the media into the intima in atherosclerosis. |
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| AbstractList | We studied the effect of acetoacetylated low-density lipoprotein (LDL), which is recognized by the scavenger receptor, on the migration of fetal bovine aortic smooth muscle cells in culture, using a Neuro Probe 48-well microchemotaxis chamber. Acetoacetylated LDL is chemotactic and chemokinetic for the smooth muscle cells, and the effect is maximal with 50 micrograms/ml of protein, while native LDL has no significant chemotactic activity. These results suggest that denatured LDL might play an important role in the recruitment of smooth muscle cells from the media into the intima in atherosclerosis. |
| Author | Funaki, C Naito, M Hayashi, T Asai, K Kuzuya, F Kuzuya, M |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/3253269$$D View this record in MEDLINE/PubMed |
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| References | 4179999 - Adv Lipid Res. 1968;6:1-68 6989919 - J Immunol Methods. 1980;33(3):239-47 214439 - J Biol Chem. 1978 Dec 25;253(24):9053-62 6184376 - J Cell Physiol. 1982 Nov;113(2):261-6 3778306 - Arteriosclerosis. 1986 Nov-Dec;6(6):601-13 6311077 - Annu Rev Biochem. 1983;52:223-61 3662843 - Artery. 1987;14(5):266-82 36810 - Anal Biochem. 1979 Jun;95(2):351-8 7076844 - J Clin Invest. 1982 Apr;69(4):1046-9 4327464 - J Cell Biol. 1971 Jul;50(1):172-86 819830 - N Engl J Med. 1976 Aug 12;295(7):369-77 3777135 - Am J Pathol. 1986 Oct;125(1):191-207 3472245 - Proc Natl Acad Sci U S A. 1987 May;84(9):2995-8 4176473 - J Lipid Res. 1968 Nov;9(6):693-700 3862109 - Proc Natl Acad Sci U S A. 1985 Sep;82(17):5949-53 |
| References_xml | – reference: 6311077 - Annu Rev Biochem. 1983;52:223-61 – reference: 3778306 - Arteriosclerosis. 1986 Nov-Dec;6(6):601-13 – reference: 3472245 - Proc Natl Acad Sci U S A. 1987 May;84(9):2995-8 – reference: 4176473 - J Lipid Res. 1968 Nov;9(6):693-700 – reference: 214439 - J Biol Chem. 1978 Dec 25;253(24):9053-62 – reference: 3862109 - Proc Natl Acad Sci U S A. 1985 Sep;82(17):5949-53 – reference: 6989919 - J Immunol Methods. 1980;33(3):239-47 – reference: 3777135 - Am J Pathol. 1986 Oct;125(1):191-207 – reference: 4327464 - J Cell Biol. 1971 Jul;50(1):172-86 – reference: 3662843 - Artery. 1987;14(5):266-82 – reference: 819830 - N Engl J Med. 1976 Aug 12;295(7):369-77 – reference: 36810 - Anal Biochem. 1979 Jun;95(2):351-8 – reference: 4179999 - Adv Lipid Res. 1968;6:1-68 – reference: 6184376 - J Cell Physiol. 1982 Nov;113(2):261-6 – reference: 7076844 - J Clin Invest. 1982 Apr;69(4):1046-9 |
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| SubjectTerms | Animals Arteriosclerosis - pathology Cattle Cell Movement Cells, Cultured Chemotaxis - drug effects Lipoproteins, LDL - pharmacology Muscle, Smooth, Vascular - cytology |
| Title | Chemotactic response of vascular smooth muscle cells to acetoacetylated low-density lipoprotein |
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