Chemotactic response of vascular smooth muscle cells to acetoacetylated low-density lipoprotein

We studied the effect of acetoacetylated low-density lipoprotein (LDL), which is recognized by the scavenger receptor, on the migration of fetal bovine aortic smooth muscle cells in culture, using a Neuro Probe 48-well microchemotaxis chamber. Acetoacetylated LDL is chemotactic and chemokinetic for...

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Published inHeart and vessels Vol. 4; no. 2; p. 100
Main Authors Naito, M, Hayashi, T, Funaki, C, Kuzuya, M, Asai, K, Kuzuya, F
Format Journal Article
LanguageEnglish
Japanese
Published Japan 01.06.1988
Subjects
Animals
Arteriosclerosis - pathology
Cattle
Cell Movement
Cells, Cultured
Chemotaxis - drug effects
Lipoproteins, LDL - pharmacology
Muscle, Smooth, Vascular - cytology
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Summary:We studied the effect of acetoacetylated low-density lipoprotein (LDL), which is recognized by the scavenger receptor, on the migration of fetal bovine aortic smooth muscle cells in culture, using a Neuro Probe 48-well microchemotaxis chamber. Acetoacetylated LDL is chemotactic and chemokinetic for the smooth muscle cells, and the effect is maximal with 50 micrograms/ml of protein, while native LDL has no significant chemotactic activity. These results suggest that denatured LDL might play an important role in the recruitment of smooth muscle cells from the media into the intima in atherosclerosis.
ISSN:0910-8327
DOI:10.1007/bf02058996