Fluorophotometric evaluation of experimental blood-aqueous barrier disruption in dogs

A protocol for performing slit-lamp fluorophotometry of the anterior chamber in dogs was established. The technique was then used to develop a model of blood-aqueous barrier disruption that can be used for comparative testing of ophthalmic anti-inflammatory drugs. It was determined that barrier disr...

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Bibliographic Details
Published inAmerican journal of veterinary research Vol. 52; no. 9; p. 1433
Main Authors Ward, D.A. (University of Georgia, Athens, GA), Ferguson, D.C, Kaswan, R.L, Green, K, Bellhorn, R.W
Format Journal Article
LanguageEnglish
Published United States 01.09.1991
Subjects
ANIMAL DE LABORATOIRE
ANIMALES DE LABORATORIO
Animals
Aqueous Humor - metabolism
Capillary Permeability
CHIEN
Dogs - metabolism
ESPECTROMETRIA
Female
FLUORIMETRIA
FLUORIMETRIE
Fluorophotometry - veterinary
Male
MODELE
MODELOS
OEIL
OJOS
PERRO
SPECTROMETRIE
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Summary:A protocol for performing slit-lamp fluorophotometry of the anterior chamber in dogs was established. The technique was then used to develop a model of blood-aqueous barrier disruption that can be used for comparative testing of ophthalmic anti-inflammatory drugs. It was determined that barrier disruption induced by a slow, controlled paracentesis of a small volume of aqueous humor may provide the most reliable model for drug testing. Additionally, fluorophotometry proved to be a sensitive and accurate means of detecting breakdown of the blood-aqueous barrier
Bibliography:L74
9166019
ISSN:0002-9645
1943-5681
DOI:10.2460/ajvr.1991.52.09.1433