Novel euglycemic and hypolipidemic agents: Part - 2 antioxidant moiety as structural motif

Several thiazolidinediones having antioxidant moities in their structural motif have been synthesised and evaluated for their euglycemic and hypolipidemic activities. A few of them have been found to be superior to troglitazone. Insertion of -N-Me-group between chroman ring and phenoxyethyl moiety l...

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Published inBioorganic & medicinal chemistry letters Vol. 8; no. 9; pp. 999 - 1002
Main Authors Reddy, K.Anji, Lohray, B.B., Bhushan, Vidya, Reddy, A.Sekar, Kishore, P.Hari, Rao, V.Venugopal, Saibaba, V., Bajji, A.C., Rajesh, B.M., Reddy, K.Vivekananda, Chakrabarti, Ranjan, Rajagopalan, R.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 05.05.1998
Elsevier
Subjects
Animals
Antioxidants - chemical synthesis
Antioxidants - chemistry
Antioxidants - pharmacology
Biological and medical sciences
Blood Glucose - metabolism
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - genetics
Drug Design
General and cellular metabolism. Vitamins
Hypoglycemic Agents - chemical synthesis
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - pharmacology
Hypolipidemic Agents - chemical synthesis
Hypolipidemic Agents - chemistry
Hypolipidemic Agents - pharmacology
Indicators and Reagents
Medical sciences
Mice
Mice, Mutant Strains
Pharmacology. Drug treatments
Structure-Activity Relationship
Thiazoles - chemical synthesis
Thiazoles - chemistry
Thiazoles - pharmacology
Triglycerides - blood
Endocrinopathy
Sulfur nitrogen heterocycle
Thiazole derivatives
Rodentia
Oral administration
Aminoether
Antioxidant
Oxygen heterocycle
Non insulin dependent diabetes
Vertebrata
Mammalia
Structure activity relation
Mouse
Animal
Phenols
Benzofuran derivatives
Chemical synthesis
Antilipemic agent
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Summary:Several thiazolidinediones having antioxidant moities in their structural motif have been synthesised and evaluated for their euglycemic and hypolipidemic activities. A few of them have been found to be superior to troglitazone. Insertion of -N-Me-group between chroman ring and phenoxyethyl moiety lead to improved antidiabetic and hypolipidemic activities compared to troglitazone.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00159-0