Alteration in synaptic junction proteins following traumatic brain injury

Extensive research and scientific efforts have been focused on the elucidation of the pathobiology of cellular and axonal damage following traumatic brain injury (TBI). Conversely, few studies have specifically addressed the issue of synaptic dysfunction. Synaptic junction proteins may be involved i...

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Published inJournal of neurotrauma Vol. 31; no. 16; pp. 1375 - 1385
Main Authors Merlo, Lucia, Cimino, Francesco, Angileri, Filippo Flavio, La Torre, Domenico, Conti, Alfredo, Cardali, Salvatore Massimiliano, Saija, Antonella, Germanò, Antonino
Format Journal Article
LanguageEnglish
Published United States Mary Ann Liebert, Inc 15.08.2014
Subjects
Animals
Brain damage
Brain Injuries - metabolism
Brain Injuries - physiopathology
Humans
Nerve Tissue Proteins - biosynthesis
Proteins
Synapses - metabolism
Trauma
traumatic brain injury
synaptic junction proteins
synaptic dysfunction
neuroproteomic
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Summary:Extensive research and scientific efforts have been focused on the elucidation of the pathobiology of cellular and axonal damage following traumatic brain injury (TBI). Conversely, few studies have specifically addressed the issue of synaptic dysfunction. Synaptic junction proteins may be involved in post-TBI alterations, leading to synaptic loss or disrupted plasticity. A Synapse Protein Database on synapse ontology identified 109 domains implicated in synaptic activities and over 5000 proteins, but few of these demonstrated to play a role in the synaptic dysfunction after TBI. These proteins are involved in neuroplasticity and neuromodulation and, most importantly, may be used as novel neuronal markers of TBI for specific intervention.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0897-7151
1557-9042
DOI:10.1089/neu.2014.3385