Cytotoxicity of novel hybrid composite materials for making bone fracture plates

• Published in: Biomedical materials (Bristol) Vol. 19; no. 4; pp. 41001 - 41008
• Main Authors: Bihari, Aurelia, Gee, Aaron, Bougherara, Habiba, Brzozowski, Pawel, Lawendy, Abdel-Rahman, Schemitsch, Emil H, Zdero, Radovan
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 01.07.2024
• Subjects: bone fracture; composites; cytotoxicity; hybrid; plates; composites; hybrid; plates; cytotoxicity; bone fracture
• ISSN: 1748-6041; 1748-605X
• DOI: 10.1088/1748-605X/ad45d6

Bone fracture plates are usually made from steel or titanium, which are much stiffer than cortical bone. This may cause bone "stress shielding" (i.e., bone resorption leading to plate loosening) and delayed fracture healing (i.e., fracture motion is less than needed to stimulate callus formation at the fracture). Thus, the authors previously designed, fabricated, and mechanically tested novel "hybrid" composites made from inorganic and organic materials as potential bone fracture plates that are more flexible to reduce these negative effects. This is the first study to measure the cytotoxicity of these composites via the survival of rat cells. Cubes of carbon fiber/flax fiber/epoxy and glass fiber/flax fiber/epoxy had better cell survival vs. Kevlar fiber/flax fiber/epoxy (57% and 58% vs. 50%). Layers and powders made of carbon fiber/epoxy and glass fiber/epoxy had higher cell survival than Kevlar fiber/epoxy (96-100% and 100% vs. 39-90%). The presence of flax fibers usually decreased cell survival. Thus, carbon and glass fiber composites (with or without flax fibers), but not Kevlar fiber composites (with or without flax fibers), may potentially be used for bone fracture plates.