Near Full-Length Genomic Characterization of Two Novel HIV-1 Unique Recombinant Forms (CRF01_AE/CRF07_BC) Among Men Who Have Sex with Men in Shijiazhuang City, Hebei Province, China

• Published in: AIDS research and human retroviruses Vol. 37; no. 12; p. 978
• Main Authors: Han, Leilei, Li, Hanping, Wang, Lijing, Jia, Lei, Han, Jingwan, Li, Tianyi, Wang, Xiaolin, Liu, Yongjian, Li, Jingyun, Lu, Jianhua, Qu, Xiaojing, He, Xuhui, Liu, Haichun, Li, Lin, Dai, Erhei
• Format: Journal Article
• Language: English
• Published: United States 01.12.2021
• Subjects: China - epidemiology; Genome, Viral; Genomics; Genotype; HIV Infections; HIV-1 - genetics; Homosexuality, Male; Humans; Male; Phylogeny; Recombination, Genetic; Sequence Analysis, DNA; Sexual and Gender Minorities; China; URF; recombination; HIV; NFLG
• ISSN: 1931-8405
• DOI: 10.1089/AID.2021.0100

Unique recombinant forms (URFs) are more likely developed among HIV-1 infections through men who have sex with men (MSM) because of cocirculation of multiple subtypes. In this study, two novel URFs deriving from two HIV-positive subjects (HB010014, HB010063) were identified in Shijiazhuang, Hebei province, China, and two sequences formed a distinct monophyletic cluster. Further recombination analysis showed that of two new URFs were consisted of circulating recombinant form (CRF)01_AE and CRF07_BC. The subregion phylogenetic analysis indicated that CRF01_AE segments were traced back to cluster 4 of CRF01_AE strains, which were prevalent among HIV-1 infections through MSM in China. New URFs being developing gradually and spreading released that more and more novel recombinant strains of HIV-1 could be developed, which means that the past prevention strategies need to be adjusted.