Glycosidase activated prodrugs for targeted cancer therapy
In this review glycosidase activated prodrugs that target cancer cells are discussed. Glycosylated prodrugs undergo enzymatic bioconversion, cleaving the prodrug to release the anticancer drug at the desired site of action, hence minimising the toxic side effects associated with many current antican...
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| Published in | Chemical Society reviews Vol. 51; no. 23; pp. 9694 - 9716 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Royal Society of Chemistry
28.11.2022
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| Subjects | |
| Online Access | Get full text |
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| Summary: | In this review glycosidase activated prodrugs that target cancer cells are discussed. Glycosylated prodrugs undergo enzymatic bioconversion, cleaving the prodrug to release the anticancer drug at the desired site of action, hence minimising the toxic side effects associated with many current anticancer drugs. In addition, the presence of the carbohydrate moiety increases the aqueous solubility of the drugs, allowing for a more effective treatment. In the past decade, significant advancements have been made in this field that have led to the development of many novel carbohydrate-based prodrugs - ranging from simple glycoconjugates to complex self-assemblies and materials, which are discussed in detail herein.
In this review glycosidase activated prodrugs that target cancer cells are discussed. |
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| Bibliography: | Thorfinnur 'Thorri' Gunnlaugsson MRIA is Professor of Chemistry at the School of Chemistry, Trinity College Dublin. His current research focuses on developing various aspects of supramolecular, material and medicinal chemistries. His work has been recognised with several awards, including a Membership to The Royal Irish Academy in 2011, the 2021 Molecular Sensors and Molecular Logic gates (MSMLG) Czarnik Award (at the 7th MSMLG meeting in Dublin July 2022), the 2014 The Institute of Chemistry of Ireland (ICI) Annual Award for Chemistry, and the 2006 Bob Hay Awarded, of the Royal Society of Chemistry, Macrocycle and Supramolecular Chemistry Interest Group. Harlei Martin completed her PhD in 2019 in Maynooth University, Ireland, in the group of Assoc. Prof. Trinidad Velasco-Torrijos. Following her PhD, she worked as an assistant lecturer in the Chemistry Department of Maynooth University. She then worked as a postdoctoral researcher with Dr Clia Bonnet in the Centre for Molecular Biophysics, CNRS Orlans campus, France. Currently, Harlei is an IRC postdoc in Trinity College Dublin in the groups of Prof. Eoin Scanlan and Prof. Thorfinnur Gunnlaugsson. Her work is focused on the development of glycosylated prodrugs for targeted cancer therapy. Laura Ramírez Lázaro obtained her BSc degree at the University of Alcalá de Henares, Madrid. She completed the last year of her undergraduate degree at Trinity College Dublin where she worked on glycosylated naphthalimide probes for imaging tumor cells utilizing the ADEPT mechanism. She was granted the Trinity College Dublin Postgraduate Research Studentship and a Studentship from the SFI funded Synthesis and Solid State Pharmaceutical Centre (SSPC), and is currently in the third year of her PhD studies. Her project is focused on the development of sugars/amino-acids conjugated naphthalimide Tröger's base scaffolds as probes for biochemical imaging. Eoin Scanlan completed his undergraduate degree at NUI Galway and his PhD at the University of St. Andrews. Following postdoctoral work at the University of Bern, Switzerland and at the University of Oxford, UK he joined the School of Chemistry in Trinity College Dublin in 2008 where he is Associate Professor of Organic and Medicinal Chemistry and a PI in the Trinity Biomedical Sciences Institute. He leads an international research team in Trinity College with a focus on new synthetic methods and the discovery of novel therapeutics, diagnostics and biomaterials. He is co-founder and CSO of Glycome Biopharma, a biotech start-up company based in Dublin. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/d2cs00379a |