Effect of digestion product of royal jelly protein on SGC-7901 gastric cancer cell

• Published in: Journal of Asia-Pacific entomology Vol. 27; no. 1; pp. 102191 - 6
• Main Authors: Fu, Li, Wang, Tianshi, Song, Jianxin
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2024; 한국응용곤충학회
• Subjects: antibacterial properties; antioxidant activity; Colony formation; digestion; entomology; Gastric cancer; health promotion; Morphological; NAD ADP-ribosyltransferase; neoplasm cells; Proliferation; Protein expression; Royal jelly; spatial memory; stomach neoplasms; therapeutics; 농학; Royal jelly; Protein expression; Proliferation; Colony formation; Gastric cancer; Morphological
• ISSN: 1226-8615; 1876-7990; 1876-7790
• DOI: 10.1016/j.aspen.2023.102191

[Display omitted] •The royal jelly protein was effective in inhibiting gastric cancer cell.•Protein expression of gastric cancer was significantly affected by royal jelly protein.•Higher content of royal jelly protein digestion presents stronger inhibit ability.•Royal jelly protein is potential in gastric cancer treatment. Royal jelly used for larvae and queens has many health-promoting properties such as spatial memory improvement, antibacterial activity and antioxidant capacity. However, the anticancer ability of the royal jelly is not unknown. In this study, effect of the royal jelly protein on SGC-7901 gastric cancer cell was investigated, and the key factors including the cell morphological, the colony formation, the proliferation, the cycle, and the expression of p53 and poly (ADP-ribose) polymerase-1 (PARP-1) proteins were analyzed. Result showed royal jelly protein was excellent in inhibiting the growth of SGC-7901gastric cancer cell. After treating with the digestion product of royal jelly protein (0.05 mg/mL～0.20 mg/mL), the morphological of gastric cancer cell significantly shrink, and both of density and quantity (1000～491) of gastric cancer cell significantly (p < 0.05) decreased. The proliferation of gastric cancer was strongest inhibited by 62.84 % of 0.20 mg/mL royal jelly protein. The expression of p53 and PARP-1 protein of gastric cancer cell was respectively enhanced (0.29～0.46) and reduced (0.51～0.42). Moreover, the higher content of royal jelly protein (0.05 mg/mL～ 0.2 mg/mL), the stronger inhibit ability of 45 SGC-7901 gastric cancer cell. In conclusion, royal jelly protein can be used as a potential food in adjunctive therapy for gastric cancer.