Antibodies to Der p 1 and Der p 2 in allergic patients

• Published in: Allergologia et immunopathologia Vol. 49; no. 2; pp. 46 - 52
• Main Authors: Cruz, Renata Harumi, Ynoue, Leandro Hideki, Aranda, Carolina Sanchez, Solé, Dirceu, Neto, Antonio Condino
• Format: Journal Article
• Language: English; Spanish
• Published: Spain Codon Publications 2021
• Subjects: Allergens; Antibodies; Asthma; Dermatitis; Dust; Food allergies; Hay fever; Immunotherapy; Rhinitis; Sample size; Variance analysis; United States > US; allergen; allergy; antibodies; Dermatophagoides pteronyssinus
• ISSN: 0301-0546; 1578-1267; 0301-0546
• DOI: 10.15586/aei.v49i2.59

Atopic individuals are characterized by increased IgE production and Th2 response if exposed to certain antigens. It is known that the mother transfers anti-mite antibodies to the fetus and newborn, IgG thru the placenta, and IgA thru breastfeeding, but it is not clear whether there is a protective mechanism mediated by them concerning the development of future allergies. This study aimed to compare the levels of IgA, IgG, and IgE antibodies specific to Der p 1 and Der p 2 between atopic and healthy individuals. Serum samples of 98 patients and 44 healthy controls were subjected to quantification for specific IgE, IgG, and IgA antibodies against Der p 1 and Der p 2 by ImmunoCap and ELISA, and subjected to statistical analysis as indicated. Atopic patients had higher serum levels of IgE, IgG, and IgA specific to Der p 1 and Der p 2. The correlation was more robust between IgE and IgG antibodies. Allergic patients produce higher levels of antibodies against Der p 1 and Der p 2 compared with healthy individuals. The mechanisms involved still require detailed studies.