Stress-protective and cross action of the extracellular reactivating factor of the microorganisms of the domains Bacteria, Archaea, and Eukaryota

• Published in: Microbiology (New York) Vol. 82; no. 5; pp. 594 - 599
• Main Authors: Vorob’eva, L. I., Khodzhaev, E. Yu, Novikova, T. M., Mulyukin, A. L., Chudinova, E. M., Kozlova, A. N., El’-Registan, G. I.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.09.2013
• Subjects: Archaea; Biomedical and Life Sciences; Experimental Articles; Haloarcula; Life Sciences; Medical Microbiology; Microbiology; Saccharomyces cerevisiae; cross effect; RF peptide reactivating factor; bacteria; HeLa cells; stress protection; yeasts; archaea
• ISSN: 0026-2617; 1608-3237
• DOI: 10.1134/S0026261713050159

Cross protection of members of the domains Bacteria, Archaea , and lower Eukaryota from stress factors due to the action of extracellular low-molecular metabolites with adaptogenic functions was shown. The adaptogen produced by Luteococcus japonicus subsp. casei and described previously as a reactivating factor (RF) was shown to protect the yeasts Saccharomyces cerevisiae , archaea Haloarcula marismorti , and the cells of higher eukaryotes (HeLa) against weak stressor impacts. Production of an archaeal extracellular metabolite with a weak adaptogenic effect of the producer cells and capable of a threefold increase in survival of heat-inactivated yeast cells was discovered. Our results confirm the similarity of the compensatory adaptive reactions in prokaryotes (bacteria and archaea) and eukaryotes.