The Role of Chemokine IL-7 in Tumor and Its Potential Antitumor Immunity

Interleukin-7 (IL-7) is a cytokine belonging to the chemokine family. It plays a key role in the differentiation, development, and maturation of T lymphocytes and B lymphocytes, which is pivotal to adaptive immunity. In addition to its role in lymphocyte development, recent studies have indicated th...

Full description

Saved in:
Bibliographic Details
Published inJournal of interferon & cytokine research Vol. 42; no. 6; p. 243
Main Authors Leilei, Zhang, Kewen, Zhou, Biao, Huang, Fang, Huang, Yigang, Wang
Format Journal Article
LanguageEnglish
Published United States 01.06.2022
Subjects
adaptive immunity
antitumor effect
IL-7
Online AccessGet more information

Cover

More Information
Summary:Interleukin-7 (IL-7) is a cytokine belonging to the chemokine family. It plays a key role in the differentiation, development, and maturation of T lymphocytes and B lymphocytes, which is pivotal to adaptive immunity. In addition to its role in lymphocyte development, recent studies have indicated the antitumor functions of IL-7 in the tumor microenvironment. In this review, we discuss the role of IL-7 in tumors and summarize its antitumor potential and clinical application in lymphoma, leukemia, breast cancer, colon cancer, and so on. Furthermore, the combinational strategies of IL-7 and other antitumor drugs have been also discussed.
ISSN:1557-7465
DOI:10.1089/jir.2021.0236