Salivary interleukin-8 levels in children suffering from type 1 diabetes mellitus

• Published in: The Journal of clinical pediatric dentistry Vol. 37; no. 4; p. 377
• Main Authors: Dakovic, D, Colic, M, Cakic, S, Mileusnic, I, Hajdukovic, Z, Stamatovic, N
• Format: Journal Article
• Language: English
• Published: United States 01.07.2013
• Subjects: Adolescent; Case-Control Studies; Child; Chronic Periodontitis - complications; Chronic Periodontitis - immunology; Chronic Periodontitis - metabolism; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - metabolism; Glycated Hemoglobin A - analysis; Humans; Interleukin-8 - analysis; Interleukin-8 - metabolism; Periodontal Index; Saliva - chemistry; Statistics, Nonparametric
• ISSN: 1053-4628
• DOI: 10.17796/jcpd.37.4.l135531h4542gj66

The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type 1 diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established. Twenty children and adolescents with Type 1 DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study. The Salivary IL-8 level was statistically significantly (p < 0.005) elevated in subjects with Type 1 DM (474.47 +/- 716.76) compared to non-diabetic control group (101.99 +/- 68.32). There was no difference (p > 0.05) in the salivary IL-8 level when subjects with Type 1 DM with concomitant periodontitis were compared to diabetics without periodontitis. When the salivary IL-8 level in subjects with Type 1 DM was correlated with the clinical parameters, no statistical significance was found. An elevated salivary IL-8 level in subjects with Type 1 DM without concomitant periodontitis plays a major role in the development of diabetic micro and macroangiopathy and pathogenesis of atherosclerosis. Consequently, this may offer a basis for the assessment of risk, prophylaxis and treatment of diabetic complications.