The effects of micromycete extracellular proteases of the Aspergillus genus on the proteins of the haemostatic system

The micromycetes of the Aspergillus genus were screened for the evaluation of their capacity to secrete extracellular proteolytic enzymes effecting proteins of the human hemostatic system. Aspergillus extracellular proteases were found to cleave chromogenic peptide substrates specific for the hemost...

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Bibliographic Details
Published inRussian journal of bioorganic chemistry Vol. 40; no. 6; pp. 634 - 639
Main Authors Osmolovskiy, A., Zvonareva, E. S., Kreyer, V. G., Baranova, N. A., Egorov, N. S.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.11.2014
Subjects
Aspergillus
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Life Sciences
Micromycetes
Organic Chemistry
proteases-activators of the hemostatic proteins
extracellular proteases of micromycetes
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Summary:The micromycetes of the Aspergillus genus were screened for the evaluation of their capacity to secrete extracellular proteolytic enzymes effecting proteins of the human hemostatic system. Aspergillus extracellular proteases were found to cleave chromogenic peptide substrates specific for the hemostatic proteins, as well as to activate some proenzymes (protein C, factor X, and prothrombin). The activation of human blood plasma X-factor by micromycete extracellular proteases was first shown.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162014060120