Factors relating to the short term effectiveness of percutaneous biliary drainage for hilar cholangiocarcinoma
AIM: TO identify factors that were related to the short term effectiveness of percutaneous transhepatic biliary drainage in cholangiocarcinoma patients and to evaluate the impact of palliative drainage on their survival. METHODS: Seventy-four patients with hilar cholan- giocarcinoma who underwent pe...
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Published in | World journal of gastroenterology : WJG Vol. 15; no. 41; pp. 5206 - 5210 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Departments of Radiology, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan,China%Departments of Internal Medicine, College of Medicine,National Cheng Kung University, Tainan 704, Taiwan, China
07.11.2009
The WJG Press and Baishideng |
Subjects | |
Online Access | Get full text |
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Summary: | AIM: TO identify factors that were related to the short term effectiveness of percutaneous transhepatic biliary drainage in cholangiocarcinoma patients and to evaluate the impact of palliative drainage on their survival. METHODS: Seventy-four patients with hilar cholan- giocarcinoma who underwent percutaneous biliary drainage were enrolled in the study. The demographic and laboratory data as well as the imaging characteristics were retrospectively analyzed to correlate with the bile output and reduction rate of serum bilirubin 1 wk after drainage. RESULTS: Patients with more bile duct visualized on percutaneous transhepatic cholangiography or absence of multiple liver metastases on imaging studies had more bile output after biliary drainage [odds ratio (OR): 8.471, P = 0.010 and OR: 1.959, P = 0.022, respectively]. Patients with prolonged prothrombin time had a slow decrease in serum bilirubin (OR: 0.437, P = 0.005). The median survival time was not significantly different in patients with low or high bile output (75 d vs 125 d, P = 0.573) or in patients with slow or rapid reduction of serum bilirubin (88 d vs 94 d, P = 0.576). CONCLUSION: The short term effectiveness of percutaneous biliary drainage was related to patient's prothrombin time or the extent of tumor involvement. It, however, had no impact on survival. |
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Bibliography: | Cholangiocarcinoma; Percutaneous biliary drainage; Treatment effectiveness Treatment effectiveness 14-1219/R F832.43 Percutaneous biliary drainage TQ464.9 Cholangiocarcinoma ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: Chuang CH and Tsai HM contributed equally to this work; Chen CY designed and performed the research; Tsai HM interpreted the imaging; Lin XZ helped with the data analysis and discussion; Chen CY and Chuang CH wrote the paper. Telephone: +886-6-2353535-2679 Fax: +886-6-2766116 Correspondence to: Chiung-Yu Chen, MD, Departments of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan, China. chiungyu@mail.ncku.edu.tw |
ISSN: | 1007-9327 2219-2840 |
DOI: | 10.3748/wjg.15.5206 |