Catheter reconstruction and dosimetric verification of MRI-only treatment planning (MRTP) for interstitial HDR brachytherapy using PETRA sequence

• Published in: Physics in medicine & biology Vol. 68; no. 3; pp. 35002 - 35013
• Main Authors: Lee, Casey Y, Kaza, Evangelia, Harris, Thomas C, O’Farrell, Desmond A, King, Martin T, Dyer, Michael A, Cormack, Robert A, Buzurovic, Ivan
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 07.02.2023
• Subjects: Brachytherapy - methods; Catheters; dosimetry; Female; Genital Neoplasms, Female - radiotherapy; gynecologic cancer; HDR brachytherapy; Humans; Magnetic Resonance Imaging - methods; MRI; MRI-only; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted - methods; treatment planning; treatment planning; gynecologic cancer; dosimetry; MRI-only; MRI; HDR brachytherapy
• ISSN: 0031-9155; 1361-6560
• DOI: 10.1088/1361-6560/acaf48

. The feasibility of MRI-only treatment planning (MRTP) for interstitial high-dose rate (HDR) brachytherapy (BT) was investigated for patients diagnosed with gynecologic cancer. . A clinical MRTP workflow utilizing a 'pointwise encoding time reduction with radial acquisition (PETRA)' sequence was proposed. This is a clinically available MRI sequence optimized to improve interstitial catheter-tissue contrast. Interstitial needles outside the obturator region were reconstructed using MR images only. For catheters penetrating through the obturator, a library-based reconstruction was proposed. In this work, dwell coordinates from the clinical CT-based reconstruction were used as the surrogate for the library-based approach. For MR-only plan, dwell times were activated and assigned as in the clinical plans. The catheter reconstruction was assessed by comparing dwell position coordinates. The dosimetric comparisons between a clinical plan and MR-only plan were assessed for physical and EQD2 dose and volume parameters for , and for clinical target volume (CTV) and , and for OARs. . Catheter reconstruction was possible using the optimized PETRA sequence on MR images. An overall reconstruction difference of 1.7 ± 0.5 mm, attributed to registration-based errors, was found compared to the CT-based reconstruction. The MRTP workflow has the potential to generate a treatment plan with an equivalent dosimetric quality compared to the conventional CT/MRI-based approach. For CTV , physical and EQD2 dose and volume parameter differences were 1.5 ± 1.9% and 0.7 ± 1.0 Gy, respectively. For OARs, DVH (EQD2) differences were -0.4 ± 1.1% (-0.2 ± 0.5 Gy), 0.5 ± 2.8% (0.2 ± 1.3 Gy) and -0.5 ± 1.4% (-0.2 ± 0.5 Gy) for rectum, bladder, and sigmoid, respectively. . With the proposed MRTP approach, CT imaging may no longer be needed in HDR BT for interstitial gynecologic treatment. A proof-of-concept study was conducted to demonstrated that MRTP using PETRA is feasible, with comparable dosimetric results to the conventional CT/MRI-based approach.