Crosstalk between angiogenesis, cytokeratin-18, and insulin resistance in the progression of non-alcoholic steatohepatitis

• Published in: World journal of gastroenterology : WJG Vol. 15; no. 41; pp. 5193 - 5199
• Main Author: Mitsuteru Kitade Hitoshi Yoshiji Ryuichi Noguchi Yasuhide Ikenaka Kosuke Kaji Yusaku Shirai Masaharu Yamazaki Masahito Uemura Junichi Yamao Masao Fujimoto Akira Mitoro Masahisa Toyohara, Masayoshi Sawai Motoyuki Yoshida Chie Morioka Tatsuhiro Tsujimoto Hideto Kawaratani Hiroshi Fukui
• Format: Journal Article
• Language: English
• Published: United States Third Department of Internal Medicine, Nara Medical University, Shijo-cho 840, Kashihara, Nara 634-8522,Japan 07.11.2009; The WJG Press and Baishideng
• Subjects: Adult; Brief; Case-Control Studies; Disease Progression; Fatty Liver - etiology; Fatty Liver - physiopathology; Female; Homeostasis - physiology; Humans; Insulin Resistance - physiology; Keratin-18 - physiology; Liver - blood supply; Liver - physiopathology; Male; Middle Aged; Neovascularization, Pathologic - physiopathology; Signal Transduction - physiology; 佛罗里达州; 细胞角蛋白; 胰岛素抵抗; 脂肪肝; 血管生成; 酒精性; Angiogenesis; Insulin resistance; Fatty liver; Liver fibrosis; Non-alcoholic steatohepatitis; Cytokeratin-18
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.15.5193

AIM： To elucidate the possible crosstalk between angiogenesis, cytokeratin-18 （CK-18）, and insulin resistance （IR） especially in patients with non-alcoholic steatohepatitis （NASH）. METHODS： Twenty-eight patients with NASH and 11 with simple fatty liver disease （FL） were enrolled in this study and underwent clinicopathological examination. The measures of angiogenesis, CK-18, and IR employed were CD34-immunopositive vessels, CK-18- immunopositive cells, and homeostasis model assessment of IR （HOMA-IR）, respectively. The correlations of these factors with NASH were elucidated. RESULTS： Significant development of hepatic neo- vascularization was observed only in NASH, whereas almost no neovascularization could be observed in FL and healthy liver. The degree of angiogenesis was almost parallel to liver fibrosis development, and both parameters were positively correlated. Similarly, CK-18 expression and HOMA-R were significantly increased in NASH as compared with FL and healthy liver. Further- more, CK-18 and HOMA-IR were also positively corre- lated with the degree of neovascularization. CONCLUSION： These results indicate that the crosstalk between angiogenesis, CK-18, and IR may play an important role in the onset and progression of NASH.