Study on Trace Sample of Chronic Skin Ulcer with a Symmetrical Optical Waveguide-Based Surface Plasmon Resonance Biosensor

A prototype of symmetrical optical waveguide (SOW)-based surface plasmon resonance (SPR) sensing system is developed. Based on a polydopamine and matrix metalloproteinase-9 (MMP-9) antibody sensing protocol, trace samples of secretions from the chronic skin ulcer are detected with the SPR sensing sy...

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Bibliographic Details
Published inPlasmonics (Norwell, Mass.) Vol. 10; no. 6; pp. 1631 - 1637
Main Authors Lin, Han, Wang, Leping, Dong, Jianxun, Xu, Xuying, Liu, Le, Zhang, Lin, Huang, Qiang, Zhang, Xuhui, Liu, Qingquan
Format Journal Article
LanguageEnglish
Published New York Springer US 01.12.2015
Subjects
Biochemistry
Biological and Medical Physics
Biophysics
Biotechnology
Chemistry
Chemistry and Materials Science
Nanotechnology
Surface plasmon resonance
Symmetrical optical waveguide
Chronic skin ulcer
Trace sample
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Summary:A prototype of symmetrical optical waveguide (SOW)-based surface plasmon resonance (SPR) sensing system is developed. Based on a polydopamine and matrix metalloproteinase-9 (MMP-9) antibody sensing protocol, trace samples of secretions from the chronic skin ulcer are detected with the SPR sensing system, and the detection results are compared with conventional enzyme-linked immunosorbent assay (ELISA) results, showing the clinical utility of the SPR detector. Considering the capability of trace sample and high-throughput detections, the SOW-based SPR sensing system has great potential in other clinical applications.
ISSN:1557-1955
1557-1963
DOI:10.1007/s11468-015-9983-5