cis and trans regulation of tissue-specific transcription

Analysis of both the cis-regulatory sequences which control globin gene switching as well as the trans-acting factors which bind to these sequences to elicit a differential, developmentally regulated response has lent insight into the general mechanisms responsible for tissue-specific gene regulatio...

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Published inJournal of cell science Vol. 16; no. Supplement_16; pp. 21 - 31
Main Authors Engel, J D, Beug, H, LaVail, J H, Zenke, M W, Mayo, K, Leonard, M W, Foley, K P, Yang, Z, Kornhauser, J M, Ko, L J
Format Journal Article
LanguageEnglish
Published England 1992
Subjects
Animals
Base Sequence
Binding Sites
Brain - embryology
Chick Embryo
DNA-Binding Proteins - genetics
Erythroid-Specific DNA-Binding Factors
Gene Expression Regulation
Genes, Switch
Globins - genetics
HIV - genetics
Mice
Molecular Sequence Data
Transcription Factors - genetics
Transcription, Genetic
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Summary:Analysis of both the cis-regulatory sequences which control globin gene switching as well as the trans-acting factors which bind to these sequences to elicit a differential, developmentally regulated response has lent insight into the general mechanisms responsible for tissue-specific gene regulation. We show here that the chicken adult beta-globin gene promoter sequences are intimately involved in competitive interaction with the beta/epsilon-globin enhancer to regulate differentially epsilon- versus beta-globin gene transcription. Secondly, we show that the family of GATA transcription factors directs gene regulation in a variety of discrete cell types, and describe potential cellular target genes for each member of the GATA factor family, as well as potential mechanisms whereby multiple GATA factors expressed in a single cell might be used to elicit differential transcriptional activities.
ISSN:0269-3518
0021-9533
1477-9137
DOI:10.1242/jcs.1992.Supplement_16.4