Inhibition of Growth of Chlamydia trachomatis by the Calcium Antagonist Verapamil
1 Department of Nephrology, Soroka Medial Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel 2 Institute of Pathology, Soroka Medial Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel 3 Virology Unit, S...
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Published in | Journal of general microbiology Vol. 135; no. 6; pp. 1619 - 1623 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
London
Soc General Microbiol
01.06.1989
New York, NY Cambridge University Press |
Subjects | |
Online Access | Get full text |
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Summary: | 1 Department of Nephrology, Soroka Medial Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel
2 Institute of Pathology, Soroka Medial Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel
3 Virology Unit, Soroka Medial Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel
ABSTRACT
Treatment of BGM (African Green Monkey kidney) cells with the calcium antagonist Verapamil resulted in a reduced yield of chlamydial infectious particles. The inhibitory effect was concentration-dependent, the maximal effect being achieved at 200 µM-Verapamil, which produced a 99·99% reduction of infectious particle yield. Electron microscopy showed that control Chlamydia trachomatis -infected BGM cells contained typical large inclusions in which most of the particles were elementary bodies, whereas Verapamil-treated infected cells contained small inclusions consisting predominantly of reticulate bodies. The findings indicate a possible therapeutic use of this calcium antagonist as an anti-chlamydial drug. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-1287 1350-0872 1465-2080 |
DOI: | 10.1099/00221287-135-6-1619 |