Two abnormal clones in the bone marrow cells of a patient with paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria (PNH) is considered to be a clonal disorder, although most investigations have failed to show chromosomal abnormalities. The present patient suffered from PNH and exhibited in bone marrow cells two abnormal clones with 47 chromosomes in addition to cells with 46 c...
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| Published in | Clinical genetics Vol. 16; no. 3; p. 178 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Denmark
01.09.1979
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Paroxysmal nocturnal hemoglobinuria (PNH) is considered to be a clonal disorder, although most investigations have failed to show chromosomal abnormalities. The present patient suffered from PNH and exhibited in bone marrow cells two abnormal clones with 47 chromosomes in addition to cells with 46 chromosomes. One clone showed trisomy 9, a finding previously reported in leukemias and myeloproliferative disorders. Thus, PNH seems to be a clonal myeloproliferative disease. |
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| AbstractList | Paroxysmal nocturnal hemoglobinuria (PNH) is considered to be a clonal disorder, although most investigations have failed to show chromosomal abnormalities. The present patient suffered from PNH and exhibited in bone marrow cells two abnormal clones with 47 chromosomes in addition to cells with 46 chromosomes. One clone showed trisomy 9, a finding previously reported in leukemias and myeloproliferative disorders. Thus, PNH seems to be a clonal myeloproliferative disease. |
| Author | Cohen, A M Klein, B Lewinski, U Shabtai, F Djaldetti, M |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/487638$$D View this record in MEDLINE/PubMed |
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| Snippet | Paroxysmal nocturnal hemoglobinuria (PNH) is considered to be a clonal disorder, although most investigations have failed to show chromosomal abnormalities.... |
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| SubjectTerms | Aged Bone Marrow - ultrastructure Chromosome Banding Chromosome Inversion Chromosomes, Human, 1-3 Chromosomes, Human, 6-12 and X Clone Cells - ultrastructure Hemoglobinuria, Paroxysmal - genetics Humans Male Trisomy |
| Title | Two abnormal clones in the bone marrow cells of a patient with paroxysmal nocturnal hemoglobinuria |
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