Two abnormal clones in the bone marrow cells of a patient with paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is considered to be a clonal disorder, although most investigations have failed to show chromosomal abnormalities. The present patient suffered from PNH and exhibited in bone marrow cells two abnormal clones with 47 chromosomes in addition to cells with 46 c...

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Bibliographic Details
Published inClinical genetics Vol. 16; no. 3; p. 178
Main Authors Cohen, A M, Shabtai, F, Lewinski, U, Klein, B, Djaldetti, M
Format Journal Article
LanguageEnglish
Published Denmark 01.09.1979
Subjects
Aged
Bone Marrow - ultrastructure
Chromosome Banding
Chromosome Inversion
Chromosomes, Human, 1-3
Chromosomes, Human, 6-12 and X
Clone Cells - ultrastructure
Hemoglobinuria, Paroxysmal - genetics
Humans
Male
Trisomy
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Summary:Paroxysmal nocturnal hemoglobinuria (PNH) is considered to be a clonal disorder, although most investigations have failed to show chromosomal abnormalities. The present patient suffered from PNH and exhibited in bone marrow cells two abnormal clones with 47 chromosomes in addition to cells with 46 chromosomes. One clone showed trisomy 9, a finding previously reported in leukemias and myeloproliferative disorders. Thus, PNH seems to be a clonal myeloproliferative disease.
ISSN:0009-9163
DOI:10.1111/j.1399-0004.1979.tb00988.x