Capillary electrophoresis in the enantioseparation of modern antidepressants: An overview
Chirality is a key subject in modern drug research as well as in the pharmaceutical industry and drug development. Almost all second‐generation modern antidepressants are chiral substances; however in therapy some are used as racemic mixtures while others are used as pure enantiomers. The developmen...
Saved in:
Published in | Biomedical chromatography Vol. 32; no. 11; pp. e4335 - n/a |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.11.2018
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Chirality is a key subject in modern drug research as well as in the pharmaceutical industry and drug development. Almost all second‐generation modern antidepressants are chiral substances; however in therapy some are used as racemic mixtures while others are used as pure enantiomers. The development of enantioseparation methods of chiral antidepressants and their metabolites is one of the keys in understanding their enantioselective drug action. For this purpose, efficient and reliable analytical methods are needed, and capillary electrophoresis has proved to be an interesting and advantageous alternative to the more frequently used chromatographic techniques. In this review electrodriven methods available for the chiral discrimination of selective serotonin reuptake inhibitors (fluoxetine, citalopram, sertraline) and selective serotonin and norepinephrine reuptake inhibitors (venlafaxine, duloxetine) are presented and discussed. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0269-3879 1099-0801 |
DOI: | 10.1002/bmc.4335 |