Synthesis, fungicidal activity and molecular docking studies of tavaborole derivatives

• Published in: Advanced Agrochem Vol. 2; no. 2; pp. 185 - 195
• Main Authors: He, Zhuo, Huang, Dai-Chuan, Guo, Dale, Deng, Fang, Sha, Qiang, Zhang, Ming-Zhi, Zhang, Wei-Hua, Gu, Yu-Cheng
• Format: Journal Article
• Language: English
• Published: KeAi Communications Co., Ltd 01.06.2023
• Subjects: Benzoxaborole; Fungicidal activity; LeuRS; Molecular docking; Synthesis
• ISSN: 2773-2371; 2773-2371
• DOI: 10.1016/j.aac.2023.05.004

Benzoxaborole, a five-membered oxaborole ring fused with a phenyl ring, has demonstrated potent pharmacological activity. In order to explore their potential applications in agriculture, five-membered and six-membered benzoxaborole derivatives were synthesized and evaluated for their fungicidal activity against six common plant pathogenic fungi in vitro. The bioassay results showed that most of the target compounds exhibited significant fungicidal activity at concentrations below 50 μg/mL, particularly the highlighted compounds 4b and 4e, which demonstrated impressive fungicidal activity superior to those of the positive controls. Molecular docking was also performed to confirm the practical value of the active compound as a potential inhibitor of Leucyl-tRNA Synthetase (LeuRS). This study indicates that the designed benzoxaborole derivatives could serve as template molecules for the development of novel fungicides.