Clinical Significance of Hyper-HDL-cholesterolemia II. Characteristics in Clinical Features

• Published in: Nihon Rōnen Igakkai zasshi Vol. 23; no. 4; pp. 413 - 421
• Main Authors: Hata, Yoshiya, Yamamoto, Minoru, Oikawa, Takamitsu, Yamauchi, Yoshio, Nagashima, Tsutomu, Fukuzawa, Tsunetoshi, Nakajima, Kumiko, Shigematsu, Hiroshi
• Format: Journal Article
• Language: Japanese
• Published: Japan The Japan Geriatrics Society 01.07.1986
• Subjects: Adult; Alcohol Drinking; Blood Pressure; Body Constitution; Cholesterol, HDL - blood; complication of hyper-HDL-cholesterolemia; Female; HDL-cholesterol; Humans; Hypercholesterolemia - blood; lipid metabolism; Lipids - blood; Male; Middle Aged; Smoking; Triglycerides - blood; VLDL-HDL cycle
• ISSN: 0300-9173
• DOI: 10.3143/geriatrics.23.413

To elucidate the clinical significance of hyper-HDL-cholesterolemia, the subjects with HDL-c above 100mg/dl were studied, serving those with HDL-c below 30mg/dl as the control. Among 22, 876 persons (male 17, 657, female 5, 219) who visited Keio Health Councelling Center for their health check from the beginning of 1981 to the end of 1984, we found 177 subjects (male 94, female 83) whose HDL-c was above 100mg/dl, and 195 subjects (male 187, female 7) whose HDL-c below 30mg/dl. Their incidence was 0.8% (male 0.5%, female 1.8%) for hyper-HDL-c vs 0.9% (male 0.9%, female 1.1%) for hypo-HDL-c. Their percent body weight deviation was -5% vs +15%, daily alcohol intake 18g (male 26g, female 7g), vs 16g (male 17g, female 4g), and cigarett smoking 6 pieces/day vs 21 pieces/day, respectively. Their total cholesterol averaged as 226mg/dl vs 197mg/dl, triglycerides as 69mg/dl vs 262mg/dl, respectively. They had no significant difference in the liver and renal function tests including blood sugar and uric acid, except for elevated γ-GTP in hyper-HDL-c group. In short, the subjects with hyper-HDL-c were rather slim with the habit of smoking less and drinking more, though the drinking had no deteriorative effect in this group, while the subjects with hypo-HDL-c were obese and high in serum triglycerides in spite of moderate drinking. These indicated that the subjects with hyper- and hypo-HDL-c were different in their constitution in particular with lipid metabolism. It may be of interest to study the complication (s) of theses two types of HDL-c group.