Comparative Efficacy of Trichlorphon and Trichlorphon/Ivermectin Combination Treatment against Anthelmintic-Resistant Cattle Nematodes in Argentina
Twenty-four Holando Argentino male calves were treated orally with 50 mg/kg body weight trichlorphon (TCF); 0.2 mg/kg body weight subcutaneous ivermectin (IVM); a combination of TCF+IVM at the same doses and administration routes; or remained untreated (control group). All calves were necropsied at...
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Published in | Parasitology research (1987) Vol. 109; no. Suppl 1; pp. 105 - 112 |
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Main Authors | , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Berlin/Heidelberg
Springer-Verlag
01.08.2011
Springer |
Subjects | |
Online Access | Get full text |
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Summary: | Twenty-four Holando Argentino male calves were treated orally with 50 mg/kg body weight trichlorphon (TCF); 0.2 mg/kg body weight subcutaneous ivermectin (IVM); a combination of TCF+IVM at the same doses and administration routes; or remained untreated (control group). All calves were necropsied at day 14 post treatment for counting and identification of worms from abomasum, small and large intestines and lungs to determine the absolute efficacy (controlled efficacy test) for each treatment. Using the faecal egg count reduction test, the efficacy was 63.7 % for TCF, 72.3 % for IVM and 99.2 % for TCF+IVM. The absolute efficacy of IVM and IVM+TCF was 100 % against
Haemonchus placei
,
Trichostrongylus axei
and
Ostertagia ostertagi
(p < 0.05). TCF showed a similar level of efficacy except against
O. ostertagi
(84.7 %). Efficacy of the treatments against
Cooperia oncophora
/
pectinata/mcmasteri
was 80.4 % for IVM, 95.7 % for TCF and 99.6 % for TCF+IVM; against
Trichostrongylus colubriformis
was 79 % for IVM, 86.2 % for TCF and 94.1 % for TCF+IVM; against
Nematodirus helvetianus
was 0 % for IVM, 100 % for TCF and 93.8 % for TCF+IVM. The efficacies of TCF, IVM and TCF+IVM were 100 % against
Oesophagostomum radiatum
and
Trichuris
spp. The efficacy of TCF against
Dictyocaulus viviparus
was 52 % and 100 % for IVM and IVM+TCF, respectively. This is the first report of
Trichostrongylus colubriformis
and
Nematodirus helvetianus
resistant to ivermectin treatment in cattle of Argentina. The TCF+IVM combination could be an alternative for the control and treatment of nematode infections including IVM-resistant strains. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0932-0113 1432-1955 |
DOI: | 10.1007/s00436-011-2407-3 |