The role of microbiota and toll-like receptors in polycystic ovary syndrome: regulatory mechanisms of androgen metabolism

Polycystic ovary syndrome (PCOS), a prevalent reproductive endocrine and metabolic disorder in gynecology, has hyperandrogenism (HA) as an essential pathophysiological alteration. PCOS patients, with or without HA, present diverse clinical manifestations. The function of intestinal or reproductive t...

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Bibliographic Details
Published inEndocrine Connections Vol. 14; no. 6
Main Authors Huang, Xueming, Wu, Liuyan, Zhang, Yunxiang, Lai, Xiaowen, Sun, Dan
Format Journal Article
LanguageEnglish
Published England Bioscientifica Ltd 01.06.2025
Bioscientifica
Subjects
androgen
microbiota
polycystic ovary syndrome (pcos)
Review
toll-like receptors (tlrs)
microbiota
androgen
toll-like receptors (TLRs)
polycystic ovary syndrome (PCOS)
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Summary:Polycystic ovary syndrome (PCOS), a prevalent reproductive endocrine and metabolic disorder in gynecology, has hyperandrogenism (HA) as an essential pathophysiological alteration. PCOS patients, with or without HA, present diverse clinical manifestations. The function of intestinal or reproductive tract microorganisms in PCOS has drawn attention in recent years and is associated with the occurrence of HA. In this article, we review the connection between the microbial alterations in the intestinal and reproductive tracts and androgens in PCOS, and elaborate on the role of TLRs in this process.
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ISSN:2049-3614
2049-3614
DOI:10.1530/EC-25-0162