Comparison of the effects of ethinyl oestradiol and conjugated equine oestrogens in oophorectomized women

Seventeen oophorectomized women were treated for 3 month periods, in random sequence, with ethinyl oestradiol 20 and 50 mug daily and conjugated equine oestrogens (Premarin)0-625 and 1-25 mg daily. The serum cholesterol, clot lysis time, plasma fibrinogen, platelet adhesiveness and activated partial...

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Bibliographic Details
Published inClinical endocrinology (Oxford) Vol. 4; no. 2; p. 131
Main Authors Bolton, C H, Ellwood, M, Hartog, M, Martin, R, Rowe, A S, Wensley, R T
Format Journal Article
LanguageEnglish
Published England 01.03.1975
Subjects
Adult
Blood Coagulation - drug effects
Blood Protein Electrophoresis
Castration
Cholesterol - blood
Estrogens, Conjugated (USP) - adverse effects
Estrogens, Conjugated (USP) - pharmacology
Ethinyl Estradiol - pharmacology
Fatigue - chemically induced
Female
Fibrinogen - analysis
Humans
Luteinizing Hormone - blood
Middle Aged
Nausea - chemically induced
Platelet Adhesiveness - drug effects
Radioimmunoassay
Thromboplastin
Triglycerides - blood
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Summary:Seventeen oophorectomized women were treated for 3 month periods, in random sequence, with ethinyl oestradiol 20 and 50 mug daily and conjugated equine oestrogens (Premarin)0-625 and 1-25 mg daily. The serum cholesterol, clot lysis time, plasma fibrinogen, platelet adhesiveness and activated partial thromboplastin time remained unchanged throughout the different oestrogen regimes. There was a significant rise of serum triglyceride levels on both doses of ethinyl oestradiol but no significant change with Premarin. Serum luteinizing hormone levels were depressed most by ethinyl oestradiol 50 mug daily, although no down to the levels in premenopausal women.
ISSN:0300-0664
DOI:10.1111/j.1365-2265.1975.tb01521.x