Renal Capsule Transplantation to Assay Angiogenesis in Skeletal Development and Repair

Renal capsule transplantation is a very helpful method to grow embryonic tissues or tumors in a vascular environment, allowing for long-term engraftment and biological analyses. This chapter describes the surgical procedure for the transplantation of embryonic skeletal elements in the renal capsule...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 2230; p. 151
Main Authors Julien, Anais, Perrin, Simon, Abou-Khalil, Rana, Colnot, Céline
Format Journal Article
LanguageEnglish
Published United States 2021
Subjects
Adventitia - growth & development
Adventitia - pathology
Animals
Bone Development - genetics
Epithelium - growth & development
Epithelium - pathology
Humans
Kidney - growth & development
Kidney - pathology
Kidney Transplantation - methods
Lymphangiogenesis - genetics
Lymphatic Vessels - cytology
Mice
Morphogenesis - genetics
Neovascularization, Pathologic - genetics
Neovascularization, Physiologic - genetics
Organogenesis - genetics
Skeletal repair
Angiogenesis
Skeletal development
Renal capsule transplantation
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Summary:Renal capsule transplantation is a very helpful method to grow embryonic tissues or tumors in a vascular environment, allowing for long-term engraftment and biological analyses. This chapter describes the surgical procedure for the transplantation of embryonic skeletal elements in the renal capsule of adult mice and points out the manipulations that can be applied for assaying the role of angiogenesis during bone development and repair.
ISSN:1940-6029
DOI:10.1007/978-1-0716-1028-2_10