Differential Diagnosis of Rare Diseases Involving Bilateral Lower Extremities with Similar 99mTc-MDP Bone Scan Patterns: Analysis of a Case Series

Here, we reported a panel of rare diseases involving bilateral lower extremities with similar imaging patterns on 99mTc-MDP bone scans. Glucose-6-phosphate dehydrogenase deficiency (G-6PD deficiency), Gaucher disease (GD), steroid-induced osteonecrosis, progressive diaphyseal dysplasia (PDD), Erdhei...

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Bibliographic Details
Published inDiagnostics (Basel) Vol. 12; no. 4; p. 910
Main Authors Sun, Zhenkui, Shen, Chentian
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 06.04.2022
MDPI
Subjects
Anemia
Beans
bilateral lower extremities
Bone marrow
bone scan
differential diagnosis
Disease
Fractures
imaging characteristics
Magnetic resonance imaging
Medical imaging
Metabolism
Pathology
Scanners
Scintigraphy
Spleen
Israel
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Summary:Here, we reported a panel of rare diseases involving bilateral lower extremities with similar imaging patterns on 99mTc-MDP bone scans. Glucose-6-phosphate dehydrogenase deficiency (G-6PD deficiency), Gaucher disease (GD), steroid-induced osteonecrosis, progressive diaphyseal dysplasia (PDD), Erdheim–Chester disease (ECD) and Langerhans cell sarcoma (LCS) were included and imaging characteristics were analyzed. The rare properties of these diseases and mimicking features on 99mTc-MDP bone scans rendered differential diagnosis difficult but necessary. We believe that the rarely known imaging features of the reported diseases will undoubtedly help nuclear medicine physicians make differential diagnoses in clinical practice.
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ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12040910