CD10 Expression Correlates with Earlier Tumour Stages and Left-Sided Tumour Location in Colorectal Cancer but Has No Prognostic Impact in a European Cohort

• Published in: Cancers Vol. 16; no. 8; p. 1473
• Main Authors: Grass, Julia-Kristin, Grupp, Katharina, Kluth, Martina, Hube-Magg, Claudia, Simon, Ronald, Kemper, Marius, Izbicki, Jakob R, Sauter, Guido, Melling, Nathaniel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.04.2024
• Subjects: Antigens; Cloning; Colon cancer; Colorectal cancer; Colorectal carcinoma; Immunohistochemistry; Leukemia; Lymph nodes; Lymphatic system; Medical prognosis; Metastases; Metastasis; Patients; Phenotypes; Survival; Survival analysis; Tumors; β-Catenin; United Kingdom > UK; United States > US; Japan; overall survival; colorectal cancer; immunohistochemistry; metalloprotease; tissue microarray; CD10
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers16081473

The role of CD10 expression in colorectal cancer has been controversially discussed in the literature. Some data suggest a predictive capacity for lymph node and liver metastases, thus influencing overall survival (OS) and disease-free survival (DFS). This study aims to analyse the relationship between CD10 expression and overall survival (OS) in a European cohort. To determine the association of CD10 expression with tumour phenotype, molecular features, and prognosis, a tissue microarray of 1469 colorectal carcinomas was analysed using immunohistochemistry and was compared with matched clinicopathologic data. CD10 expression correlated with earlier tumour stages ( = 0.017) and left-sided colon cancer ( < 0.001). However, no correlation was found between CD10 expression and lymph node involvement ( = 0.711), tumour grading ( = 0.397), or overall survival ( = 0.562). Even in the subgroup analysis of tumour or nodal stage, CD10 did not affect overall survival, although it was significantly associated with p53 and nuclear β-catenin expression ( = 0.013 and < 0.001, respectively). CD10 expression correlates with earlier tumour stages, colon cancer location, and indicators of aggressive CRC subtypes. However, we can exclude CD10 as a relevant independent prognosticator for CRC.