Genetical and epidemiological studies of polydactyly in Hungary

Polydactyly is one of the most frequently observed human congenital limb malformations. Sporadic cases of polydactyly have been described, but most show an autosomal dominant pattern of inheritance. The purpose of this study was to investigate the frequency of polydactyly among children born between...

Full description

Saved in:
Bibliographic Details
Published inAnthropologischer Anzeiger Vol. 61; no. 4; p. 413
Main Author Bellovits, Orsolya
Format Journal Article
LanguageEnglish
Published Germany 01.12.2003
Subjects
Birth Weight
Female
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
Humans
Hungary - epidemiology
Infant
Infant, Newborn
Male
Maternal Age
Polydactyly - epidemiology
Polydactyly - genetics
Risk Factors
Severity of Illness Index
Sex Distribution
Twins - genetics
Twins - statistics & numerical data
Hungary
Online AccessGet more information

Cover

More Information
Summary:Polydactyly is one of the most frequently observed human congenital limb malformations. Sporadic cases of polydactyly have been described, but most show an autosomal dominant pattern of inheritance. The purpose of this study was to investigate the frequency of polydactyly among children born between 1980 and 1997 in Hungary. The predominance of the postaxial type over the preaxial one was less than expected. These malformations affected significantly more boys than girls. The proportion of children with low birth weight affected by polydactyly was higher than expected. Among mothers giving life to offspring with polydactyly, the prevalence was high in the older age group. We analysed the regional distribution in Hungary and the twin frequency in connection with polydactyly. From our results comparing it to the current literature data we made conclusions about the possible causes of the development of polydactyly.
ISSN:0003-5548
DOI:10.1127/anthranz/61/2003/413