Induced pluripotent stem cells

Induced pluripotent stem cells (iPS) result from a reprogramming of somatic cells via transduction with viral vectors expressing the Oct4, Sox2, c-Myc, Klf4, Nanog , and Lin28 genes, which are essential for the establishment and maintenance of the pluripotent state. In properties, iPS are almost ful...

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Published inRussian journal of genetics Vol. 45; no. 2; pp. 139 - 146
Main Authors Shevchenko, A. I., Medvedev, S. P., Mazurok, N. A., Zakian, S. M.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.02.2009
Subjects
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Human Genetics
Microbial Genetics and Genomics
Reviews and Theoretical Articles
Pluripotent State
Pluripotent Stem Cell
Somatic Cell
Neural Stem Cell
Embryonic Stem Cell
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Summary:Induced pluripotent stem cells (iPS) result from a reprogramming of somatic cells via transduction with viral vectors expressing the Oct4, Sox2, c-Myc, Klf4, Nanog , and Lin28 genes, which are essential for the establishment and maintenance of the pluripotent state. In properties, iPS are almost fully similar to embryonic stem cells (ESC). To date, iPS have been obtained from various differentiated cells of mice and humans. Along with ESC, iPSs are highly promising for research and medicine.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795409020021